Technical Data

037172
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E FC WB
Crossreactivity
Hu
Accession #
NP_000205.1
Gene ID
182
Gene #
JAG1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-JAG1, CT (JAG1, JAGL1, Protein jagged-1, CD339)
JAG1, JAGL1, Protein jagged-1, CD339

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Applications
Suitable for use in Western Blot, Indirect Flow Cytometry and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Flow Cytometry (Indirect): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1122-1150 in the C-terminal region of human JAG1. Species Sequence Homology: mouse and rat
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Purity
Purified by Protein A and peptide affinity chromatography
Specificity
Recognizes human JAG1

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Foldi, J., et al. J. Immunol. 185(9):5023-5031 (2010). 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010). 3. Kerns, D., et al. Schizophr. Res. 120 (1-3), 150-158 (2010). 4. Siar, C.H., et al. Eur. J. Med. Res. 15(4):180-184 (2010). 5. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)
USBio References
No references available
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