037319
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
Hu MoAccession #
NP_001030176.1; NP_079497.2Gene ID
80333Gene #
KCNIP4Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-KCNIP4, NT (KCNIP4, CALP, KCHIP4, Kv channel-interacting protein 4, A-type potassium channel modulatory protein 4, Calsenilin-like protein, Potassium channel-interacting protein 4)
KCNIP4, CALP, KCHIP4, Kv channel-interacting protein 4, A-type potassium channel modulatory protein 4, Calsenilin-like protein, Potassium channel-interacting protein 4
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KCNIP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human KCNIP4.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Horinouchi, M., et al. Pediatr Hematol Oncol 27(5):344-354(2010)|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Lin, L., et al. Mol. Cell. Neurosci. 43(3):315-325(2010)|Ding, H., et al. Stroke 41(1):177-180(2010)|Trynka, G., et al. Gut 58(8):1078-1083(2009)USBio References
No references available