Technical Data

037323
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu Mo
Accession #
NP_034732.1
Gene ID
16514
Gene #
Kcnj11
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-Kcnj11, NT (Kcnj11, ATP-sensitive inward rectifier potassium channel 11, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11)
Kcnj11, ATP-sensitive inward rectifier potassium channel 11, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity).

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Mouse Kcnj11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of mouse Kcnj11.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human, mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Hugill, A., et al. Diabetologia 53(11):2352-2356(2010)|Li, J., et al. J. Biol. Chem. 285(37):28723-28730(2010)|Marhfour, I., et al. Cell Tissue Res. 340(2):335-346(2010)|Kurata, H.T., et al. PLoS Biol. 8 (2), E1000315 (2010) :|Alekseev, A.E., et al. Cell Metab. 11(1):58-69(2010)
USBio References
No references available
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