037345
Clone Type
PolyclonalHost
RabbitSource
MouseIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
MoAccession #
NP_004510.1; O43525Gene ID
3786Gene #
KCNQ3Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-KCNQ3, CT (KCNQ3, Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv7.3)
KCNQ3, Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv7.3
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KCNQ3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 650-679 amino acids from the C-terminal region of human KCNQ3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :|Gomez-Posada, J.C., et al. J. Neurosci. 30(27):9316-9323(2010)|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)|Hahn, A., et al. Brain Dev. 31(7):515-520(2009)USBio References
No references available