Technical Data

037916
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu Mo
Accession #
NP_004802.1; O60711
Gene ID
9404
Gene #
LPXN
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-LPXN, ID (LPXN, LDLP, Leupaxin)
LPXN, LDLP, Leupaxin

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
LPXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the Central region of human LPXN.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human, mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Tanaka, T., et al. Cancer Sci. 101(2):363-368(2010)|Dai, H.P., et al. Genes Chromosomes Cancer 48(12):1027-1036(2009)|Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)|Sundberg-Smith, L.J., et al. Circ. Res. 102(12):1502-1511(2008)
USBio References
No references available
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