Technical Data

038496
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_258428.2
Gene ID
79258
Gene #
MMEL1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-MMEL1, NT (MMEL1, MELL1, MMEL2, NEP2, Membrane metallo-endopeptidase-like 1, Membrane metallo-endopeptidase-like 2, NEP2(m), Neprilysin II, Neprilysin-2, Membrane metallo-endopeptidase-like 1, soluble form, Neprilysin-2 secreted)
MMEL1, MELL1, MMEL2, NEP2, Membrane metallo-endopeptidase-like 1, Membrane metallo-endopeptidase-like 2, NEP2(m), Neprilysin II, Neprilysin-2, Membrane metallo-endopeptidase-like 1, soluble form, Neprilysin-2 secreted

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
MMEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human MMEL1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
van der Helm-van Mil, A.H., et al. Ann. Rheum. Dis. 69(9):1694-1696(2010)|Hirschfield, G.M., et al. Nat. Genet. 42(8):655-657(2010)|Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)|Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)|Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
USBio References
No references available
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