038499
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E IHC WBCrossreactivity
HuAccession #
NP_005931.2Gene ID
4320Gene #
MMP11Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-MMP11, CT (MMP11, STMY3, Stromelysin-3, Matrix metalloproteinase-11)
MMP11, STMY3, Stromelysin-3, Matrix metalloproteinase-11
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
MMP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 398-428 amino acids from the C-terminal region of human MMP11.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :|Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Nalpas, B., et al. Gut 59(8):1120-1126(2010)|Ban, J.Y., et al. Life Sci. 86 (19-20), 756-759 (2010) :|Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :USBio References
No references available