Technical Data

038516
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_071757.4
Gene ID
64210
Gene #
MMS19
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-MMS19, ID (MMS19, MMS19L, MMS19 nucleotide excision repair protein homolog, MET18 homolog, MMS19-like protein)
MMS19, MMS19L, MMS19 nucleotide excision repair protein homolog, MET18 homolog, MMS19-like protein

MMS19 may play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. May also function as a transcriptional coactivator of estrogen receptor (ER). May be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
MMS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 410-437 amino acids selected from the Central region of human MMS19.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Ito, S., et al. Mol. Cell 39(4):632-640(2010)|Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)|McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18(4):1295-1302(2009)|Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :|Hatfield, M.D., et al. DNA Repair (Amst.) 5(8):914-924(2006)
USBio References
No references available
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