Technical Data

038705
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu Mo
Accession #
NP_958437.1
Gene ID
63915
Gene #
MUTED
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-MUTED, ID (MUTED, Protein Muted homolog)
MUTED, Protein Muted homolog

This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene.

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
MUTED antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-76 amino acids from the Central region of human MUTED.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human, mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Morris, D.W., et al. Biol. Psychiatry 63(1):24-31(2008)|Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)|Starcevic, M., et al. J. Biol. Chem. 279(27):28393-28401(2004)|Li, W., et al. Nat. Genet. 35(1):84-89(2003)|Ciciotte, S.L., et al. Blood 101(11):4402-4407(2003)
USBio References
No references available
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