Technical Data

038910
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Purified
Applications
E WB
Crossreactivity
Hu Mo
Gene ID
4760
Gene #
NEUROD1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-NeuroD1, CT (NEUROD1, BHLHA3, NEUROD, Neurogenic differentiation factor 1, Class A basic helix-loop-helix protein 3)
NEUROD1, BHLHA3, NEUROD, Neurogenic differentiation factor 1, Class A basic helix-loop-helix protein 3

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:1,000
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
NeuroD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326~355 amino acids from the C-terminal region of human NeuroD1 protein.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation
Specificity
Human, mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Miyachi, T., et al., Brain Res. Mol. Brain Res. 69(2):223-231 (1999). Malecki, M.T., et al., Nat. Genet. 23(3):323-328 (1999). Acharya, H.R., et al., Biochem. Biophys. Res. Commun. 233(2):459-463 (1997). Yokoyama, M., et al., Brain Res. Mol. Brain Res. 42(1):135-139 (1996).
USBio References
No references available
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