039126
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_000167.1Gene ID
2908Gene #
NR3C1Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-NR3C1, CT (NR3C1, GRL, Glucocorticoid receptor, Nuclear receptor subfamily 3 group C member 1)
NR3C1, GRL, Glucocorticoid receptor, Nuclear receptor subfamily 3 group C member 1
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 560-588 amino acids from the C-terminal region of human NR3C1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Seitz, T., et al. J. Mol. Biol. 403(4):562-577(2010)|Wang, W., et al. Nucleic Acids Res. (2010) In press :|Sarzynski, M.A., et al. Int J Obes (Lond) (2010) In press :|Desrivieres, S., et al. Addict Biol (2010) In press :|van Oosten, M.J., et al. Arthritis Res. Ther. 12 (4), R159 (2010) :USBio References
No references available