039185
Clone Type
PolyclonalHost
RabbitSource
MouseIsotype
IgGGrade
Affinity PurifiedApplications
E IHC WBCrossreactivity
Hu MoAccession #
NP_001020245.1; NP_032771.1Gene ID
18212Gene #
Ntrk2Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-Ntrk2, ID (Ntrk2, Trkb, BDNF/NT-3 growth factors receptor, GP145-TrkB/GP95-TrkB, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase)
Ntrk2, Trkb, BDNF/NT-3 growth factors receptor, GP145-TrkB/GP95-TrkB, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Applications
Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within aa342-372 amino acids from the Central region of Mouse Ntrk2 (NP_001020245.1; NP_032771.1).
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes mouse Ntrk2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Xu, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):19126-19131(2010) 2. Lobo, M.K., et al. Science 330(6002):385-390(2010) 3. Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010) 4. Nikoletopoulou, V., et al. Nature 467(7311):59-63(2010) 5. Ohnishi, H., et al. J. Neurosci. 30(31):10472-10483(2010)USBio References
No references available