Technical Data

039240
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_072089
Gene ID
60506
Gene #
NYX
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-NYX, NT (NYX, CLRP, Nyctalopin)
NYX, CLRP, Nyctalopin

The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq].

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
NYX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59~89 amino acids from the N-terminal region of human NYX.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
?Leroy, B.P., et al. Br J Ophthalmol 93(5):692-696(2009)|?Zhang, Q., et al. Mol. Vis. 13, 330-336 (2007) |?Morgans, C.W., et al. Eur. J. Neurosci. 23(5):1163-1171(2006)|?Xiao, X., et al. J. Hum. Genet. 51(7):634-640(2006)
USBio References
No references available
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