039243
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
PurifiedApplications
E IHC WBCrossreactivity
Hu MoGene ID
4938Gene #
OAS1Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-OAS1, CT (OAS1, OIAS, 2'-5'-oligoadenylate synthase 1, E18/E16, p46/p42 OAS)
OAS1, OIAS, 2'-5'-oligoadenylate synthase 1, E18/E16, p46/p42 OAS
OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
OAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309~339 amino acids selected from the C-terminal region of human OAS1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).|Sarkar, S.N., et al., J. Biol. Chem. 274(36):25535-25542 (1999).|Ghosh, A., et al., J. Biol. Chem. 272(52):33220-33226 (1997).|Ghosh, S.K., et al., J. Biol. Chem. 266(23):15293-15299 (1991).|Rutherford, M.N., et al., EMBO J. 7(3):751-759 (1988).USBio References
No references available