Technical Data

039785
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_002588.3
Gene ID
5132
Gene #
PDC
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PDC, ID (PDC, Phosducin, 33kD phototransducing protein, Protein MEKA)
PDC, Phosducin, 33kD phototransducing protein, Protein MEKA

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-89 amino acids from the Central region of human PDC.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Beetz, N., et al. J. Clin. Invest. 119(12):3597-3612(2009)|Klenk, C., et al. J. Biol. Chem. 281(13):8357-8364(2006)|Nishiguchi, K.M., et al. Mol. Vis. 10, 62-64 (2004) :|Margulis, A., et al. Mol. Vis. 8, 477-482 (2002) :|Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net