039792
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_037506.2Gene ID
10015Gene #
PDCD6IPShipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-PDCD6IP, ID (PDCD6IP, AIP1, ALIX, KIAA1375, Programmed cell death 6-interacting protein, ALG-2-interacting protein 1, Hp95)
PDCD6IP, AIP1, ALIX, KIAA1375, Programmed cell death 6-interacting protein, ALG-2-interacting protein 1, Hp95
This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 541-570 in the central region of human PDCD6IP.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human PDCD6IP.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Shi, X., et al. Biochem. J. 431(1):93-102(2010) Irie, T., et al. Virology 405(2):334-341(2010) Sette, P., et al. J. Virol. 84(16):8181-8192(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Inuzuka, T., et al. BMC Struct. Biol. 10, 25 (2010) :USBio References
No references available