Technical Data

039809
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Mo
Accession #
NP_006196.1
Gene ID
5149
Gene #
PDE6H
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PDE6H, ID (PDE6H, Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma)
PDE6H, Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Lamesch, P., et al. Genomics 89(3):307-315(2007)|Piri, N., et al. Ophthalmology 112(1):159-166(2005)|Kajimura, N., et al. J. Struct. Biol. 139(1):27-38(2002)|Shimizu-Matsumoto, A., et al. Genomics 32(1):121-124(1996)
USBio References
No references available
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