Technical Data

039815
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Purified
Applications
E IHC WB
Crossreactivity
Hu
Gene ID
56034
Gene #
PDGFC
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PDGFC, NT (PDGFC, SCDGF, Platelet-derived growth factor C, Fallotein, Spinal cord-derived growth factor, VEGF-E, Platelet-derived growth factor C, latent form, Platelet-derived growth factor C, receptor-binding form)
PDGFC, SCDGF, Platelet-derived growth factor C, Fallotein, Spinal cord-derived growth factor, VEGF-E, Platelet-derived growth factor C, latent form, Platelet-derived growth factor C, receptor-binding form

Platelet-derived growth factor C (PDGFC) is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFC seems to form only homodimers, where the dimers are connected by disulfide bonds. It differs from the platelet-derived growth factor alpha (PDGFA) and beta (PDGFB) in having an unusual N-terminal domain, the CUB domain.

Applications
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: Formalin fixed paraffin embedded. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 74-103 from the N-terminal region of human PDGFC.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation
Specificity
Recognizes human PDGFC.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Fang, L., et al., Arterioscler. Thromb. Vasc. Biol. 24(4):787-792 (2004). 2. Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003). 3. Eitner, F., et al., J. Am. Soc. Nephrol. 14(5):1145-1153 (2003). 4. Reigstad, L.J., et al., J. Biol. Chem. 278(19):17114-17120 (2003). 5. Zwerner, J.P., et al., Oncogene 21(24):3847-3854 (2002).
USBio References
No references available
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