Technical Data

039966
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Mo
Accession #
NP_003915.2
Gene ID
8929
Gene #
PHOX2B
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PHOX2B, ID (PHOX2B, PMX2B, Paired mesoderm homeobox protein 2B, Neuroblastoma Phox, PHOX2B homeodomain protein, Paired-like homeobox 2B)
PHOX2B, PMX2B, Paired mesoderm homeobox protein 2B, Neuroblastoma Phox, PHOX2B homeodomain protein, Paired-like homeobox 2B

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq].

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PHOX2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the Central region of human PHOX2B.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rudzinski, E., et al. Pediatr. Dev. Pathol. 13(4):291-299(2010)|Janoueix-Lerosey, I., et al. Oncogene 29(11):1566-1579(2010)|Tu, E., et al. Hum. Pathol. 41(3):392-400(2010)|Arai, H., et al. J. Hum. Genet. 55(1):4-7(2010)|Dubreuil, V., et al. J. Neurosci. 29(47):14836-14846(2009)
USBio References
No references available
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