Technical Data

039997
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_002640
Gene ID
5294
Gene #
PIK3CG
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PI3KCG, CT (PIK3CG, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110kD catalytic subunit gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p120-PI3K)
PIK3CG, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110kD catalytic subunit gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p120-PI3K

PI3KCG belongs to the pi3/pi4-kinase family of proteins. This protein is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells.

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot 1:100-500 Immunohistochemistry: 1:50-100
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PI3KCG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1073~1102 amino acids from the C-terminal region of human PI3KCG.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Resendiz, J.C., et al., Mol. Pharmacol. 63(3):639-645 (2003).|Francois, F., et al., J. Virol. 77(4):2539-2549 (2003).|Chandrasekar, N., et al., Oncogene 22(3):392-400 (2003).|Ishibashi, Y., et al., Cell. Microbiol. 4(12):825-833 (2002).|Semba, S., et al., Clin. Cancer Res. 8(12):3824-3831 (2002).
USBio References
No references available
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