Technical Data

040044
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_443112.2
Gene ID
113791
Gene #
PIK3IP1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PIK3IP1, CT (PIK3IP1, HGFL, Phosphoinositide-3-kinase-interacting protein 1, Kringle domain-containing protein HGFL)
PIK3IP1, HGFL, Phosphoinositide-3-kinase-interacting protein 1, Kringle domain-containing protein HGFL

PIK3IP1 is a novel protein that shares homology with the p85 subunit of phosphatidylinositol-3-Kinases (PI3Ks). The PI3K is essential for cell proliferation and Survival. The PIK3IP down regulates the activity of the PI3K and induces apoptosis by associating with p85 and p110 to form a complex, using the p85-like domain. However, there is no evidence to suggest that the PIK3IP1 prevents association of p85 and p110 as they associate with very high affinity.

Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 178-207 the C-terminal region of human PIK3IP1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human PIK3IP1

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Gao, P., et al. Beijing Da Xue Xue Bao 40(6):572-577(2008) 2. He, X., et al. Cancer Res. 68(14):5591-5598(2008) 3. Zhu, Z., et al. Biochem. Biophys. Res. Commun. 358(1):66-72(2007) 4. Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004) 5. Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
USBio References
No references available
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