Technical Data

040108
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_004563.2
Gene ID
5318
Gene #
PKP2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PKP2, CT (PKP2, Plakophilin-2)
PKP2, Plakophilin-2

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.

Applications
Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 838-866 in the C-terminal region of human PKP2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human PKP2.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Fressart, V., et al. Europace 12(6):861-868(2010). 2. Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010). 3. Christensen, A.H., et al. Cardiology 115(2):148-154(2010). 4. den Haan, A.D., et al. Circ Cardiovasc Genet 2(5):428-435(2009). 5. Bhuiyan, Z.A., et al. Circ Cardiovasc Genet 2(5):418-427(2009)
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net