Technical Data

040458
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
O43422; NP_004696.2
Gene ID
5612
Gene #
PRKRIR
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PRKRIR, NT (PRKRIR, DAP4, P52RIPK, THAP0, 52kD repressor of the inhibitor of the protein kinase, 58kD interferon-induced protein kinase-interacting protein, Death-associated protein 4, THAP domain-containing protein 0)
PRKRIR, DAP4, P52RIPK, THAP0, 52kD repressor of the inhibitor of the protein kinase, 58kD interferon-induced protein kinase-interacting protein, Death-associated protein 4, THAP domain-containing protein 0

Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PRKRIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the N-terminal region of human PRKRIR.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)|Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :|Lee, J.H., et al. Korean J Gastroenterol 42(6):484-495(2003)|Lin, Y., et al. J. Biol. Chem. 277(50):47991-48001(2002)|Saelens, X., et al. J. Biol. Chem. 276(45):41620-41628(2001)
USBio References
No references available
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