Technical Data

040475
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IF IHC WB
Crossreactivity
Hu
Accession #
NP_000303.1
Gene ID
5624
Gene #
PROC
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PROC, ID (PROC, Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide)
PROC, Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunofluorescence: 1:10-50 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PROC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-206 amino acids from the Central region of human PROC.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Tang, W., et al. Blood (2010) In press :|Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44(4):613-619(2010)|Witt, I., et al. Blood Coagul. Fibrinolysis 5(4):651-653(1994)|Zhang, L., et al. Blood 80(4):942-952(1992)|Grundy, C.B., et al. Hum. Genet. 89(6):683-684(1992)
USBio References
No references available
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