040539
Clone Type
PolyclonalHost
RabbitSource
MouseIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
MoAccession #
NP_004219.3Gene ID
9266Gene #
CYTH2Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-PSCD2, NT (CYTH2, ARNO, PSCD2, PSCD2L, Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, PH, SEC7 and coiled-coil domain-containing protein 2)
CYTH2, ARNO, PSCD2, PSCD2L, Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, PH, SEC7 and coiled-coil domain-containing protein 2
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PSCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-64 amino acids from the N-terminal region of human PSCD2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Merkulova, M., et al. Biochim. Biophys. Acta 1797(8):1398-1409(2010)|Torii, T., et al. J. Biol. Chem. 285(31):24270-24281(2010)|White, D.T., et al. Mol. Biol. Cell 21(4):562-571(2010)|Bouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007) :|Wu, C., et al. Proteomics 7(11):1775-1785(2007)USBio References
No references available