Technical Data

040542
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu Mo
Gene ID
5671
Gene #
PSG3
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-PSG3, NT (PSG3, Pregnancy-specific beta-1-glycoprotein 3, Carcinoembryonic antigen SG5)
PSG3, Pregnancy-specific beta-1-glycoprotein 3, Carcinoembryonic antigen SG5

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
PSG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29~58 amino acids from the N-terminal region of human PSG3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human, mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)|Grimwood, J., et al. Nature 428(6982):529-535(2004)|Teglund, S., et al. Genomics 23(3):669-684(1994)|Olsen, A., et al. Genomics 23(3):659-668(1994)|Shupert, W.L., et al. Mol. Cell. Biochem. 120(2):159-170(1993)
USBio References
No references available
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