Technical Data

040917
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_004405.3; NP_981963.1
Gene ID
1827
Gene #
RCAN1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-RCAN1, NT (RCAN1, ADAPT78, CSP1, DSC1, DSCR1, Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, Regulator of calcineurin 1)
RCAN1, ADAPT78, CSP1, DSC1, DSCR1, Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, Regulator of calcineurin 1

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
RCAN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the N-terminal region of human RCAN1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Tam, G.W., et al. Biochem. Soc. Trans. 38(2):445-451(2010)|Lee, M.Y., et al. Hum. Mol. Genet. 19(3):468-479(2010)|Sales, K.J., et al. Am. J. Pathol. 176(1):435-445(2010)|Sales, K.J., et al. Biochim. Biophys. Acta 1793(12):1917-1928(2009)
USBio References
No references available
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