Technical Data

041168
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_008845.2
Gene ID
6096
Gene #
RORB
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-RORB, CT (RORB, NR1F2, RZRB, Nuclear receptor ROR-beta, Nuclear receptor RZR-beta, Nuclear receptor subfamily 1 group F member 2, Retinoid-related orphan receptor-beta)
RORB, NR1F2, RZRB, Nuclear receptor ROR-beta, Nuclear receptor RZR-beta, Nuclear receptor subfamily 1 group F member 2, Retinoid-related orphan receptor-beta

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.

Applications
Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 329-358 in the C-terminal region of human RORB. Species Sequence Homology: mouse and rat
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Purity
Purified by Protein A and peptide affinity chromatography
Specificity
Recognizes human RORB

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010). 2. Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010). 3. Mansour, H.A., et al. Bipolar Disord 11(7):701-710(2009). 4. McGrath, C.L., et al. BMC Psychiatry 9, 70 (2009). 5. Humphray, S.J., et al. Nature 429(6990):369-374(2004)
USBio References
No references available
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