Technical Data

041169
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001001523.1; NP_005051.2
Gene ID
6097
Gene #
RORC
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-RORC, ID (RORC, NR1F3, RORG, RZRG, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Retinoid-related orphan receptor-gamma)
RORC, NR1F3, RORG, RZRG, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Retinoid-related orphan receptor-gamma

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
RORC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-216 amino acids from the Central region of human RORC.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Wang, Y., et al. Biochim. Biophys. Acta 1801(8):917-923(2010)|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Burgler, S., et al. J. Immunol. 184(11):6161-6169(2010)|Jin, L., et al. Mol. Endocrinol. 24(5):923-929(2010)|Wang, W.J., et al. J. Reprod. Immunol. 84(2):164-170(2010)
USBio References
No references available
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