041365
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_001159687.1; NP_110387.1Gene ID
53637Gene #
S1PR5Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-S1PR5, ID (S1PR5, EDG8, Sphingosine 1-phosphate receptor 5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8)
S1PR5, EDG8, Sphingosine 1-phosphate receptor 5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.
Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 218-247 in the central region of human S1PR5.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human S1PR5.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Chang, C.L., et al. Am. J. Physiol., Cell Physiol. 297 (2), C451-C458 (2009) : 2. Gillies, L., et al. Cell. Signal. 21(5):675-684(2009) 3. Miron, V.E., et al. Ann. Neurol. 63(1):61-71(2008) 4. Ulfig, N., et al. Acta Histochem. 106(5):373-378(2004) 5. Vogler, R., et al. J. Invest. Dermatol. 120(4):693-700(2003)USBio References
No references available