Technical Data

041399
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E FC IHC WB
Crossreactivity
Hu
Accession #
NP_057187.1; NP_001028675.1
Gene ID
51128
Gene #
SAR1B
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SAR1B, ID (SAR1B, SARA2, SARB, GTP-binding protein SAR1b, GTP-binding protein B)
SAR1B, SARA2, SARB, GTP-binding protein SAR1b, GTP-binding protein B

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Indirect Flow Cytometry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100 Indirect Flow Cytometry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
SAR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of human SAR1B.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Cefalu, A.B., et al. Metab. Clin. Exp. 59(4):463-467(2010)|Silvain, M., et al. Clin. Genet. 74(6):546-552(2008)|Charcosset, M., et al. Mol. Genet. Metab. 93(1):74-84(2008)|Jardim, D.L., et al. J. Biochem. Mol. Biol. 38(3):328-333(2005)|Jones, B., et al. Nat. Genet. 34(1):29-31(2003)
USBio References
No references available
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