Technical Data

041585
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E FC WB
Crossreactivity
Hu
Accession #
NP_000593.1; NP_001158885.1
Gene ID
5054
Gene #
SERPINE1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SERPINE1, ID (SERPINE1, PAI1, PLANH1, Plasminogen activator inhibitor 1, Endothelial plasminogen activator inhibitor, Serpin E1)
SERPINE1, PAI1, PLANH1, Plasminogen activator inhibitor 1, Endothelial plasminogen activator inhibitor, Serpin E1

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, Indirect Flow Cytometry and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 188-216 in the central region of human SERPINE1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human SERPINE1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Ma, Z., et al. Biochem. Biophys. Res. Commun. 400(4):569-574 (2010). 2. Ince, D.A., et al. Genet Test Mol Biomarkers 14(5):643-647 (2010). 3. Bern, M.M., et al. Clin. Appl. Thromb. Hemost. 16(5):574-578 (2010). 4. Markl, B., et al. J Surg Oncol 102(3):235-241 (2010). 5. de Haas, E.C., et al. Cancer (2010)
USBio References
No references available
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