041647-PE
Clone Type
PolyclonalHost
RabbitSource
HumanConjugate
PEIsotype
IgGGrade
Affinity PurifiedApplications
FLISA WBCrossreactivity
HuAccession #
NP_001129169.1; NP_000014.1Gene ID
6442Gene #
SGCAShipping Temp
Blue IceStorage Temp
4°C Do Not FreezeNotes
Preservative Free
Rabbit Anti-SGCA, ID (SGCA, ADL, DAG2, Alpha-sarcoglycan, 50kD dystrophin-associated glycoprotein, Adhalin, Dystroglycan-2) (PE)
SGCA, ADL, DAG2, Alpha-sarcoglycan, 50kD dystrophin-associated glycoprotein, Adhalin, Dystroglycan-2
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications
Suitable for use in Western Blot and FLISA. Other applications have not been tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 239-266 in the central region of human SGCA, Swiss/UniProt Accession: Q16586.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human SGCA.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Mendell, J.R., et al. Ann. Neurol. 68(5):629-638(2010) 2. Fernandez, K., et al. Am. J. Pathol. 176(1):416-434(2010) 3. Klinge, L., et al. Neuromuscul. Disord. 18(12):934-941(2008) 4. Delgado-Olguin, P., et al. Biochim. Biophys. Acta 1779(1):74-80(2008) 5. Rafii, M.S., et al. J. Cell. Physiol. 209(2):439-447(2006)USBio References
No references available