041700
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
Hu MoAccession #
NP_001028478.1Gene ID
230126Gene #
ShbShipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-Shb, CT (Shb, SH2 domain-containing adapter protein B)
Shb, SH2 domain-containing adapter protein B
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity).
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Mouse Shb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-95 amino acids from the C-terminal region of mouse Shb.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human, mouse (predicted)
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Calounova, G., et al. PLoS ONE 5 (6), E11155 (2010) :|Akerblom, B., et al. J. Endocrinol. 203(2):271-279(2009)|Mokhtari, D., et al. Biochem. Biophys. Res. Commun. 387(3):553-557(2009)|Funa, N.S., et al. Cancer Res. 69(5):2141-2148(2009)|Funa, N.S., et al. Differentiation 76(5):443-453(2008)USBio References
No references available