Technical Data

041770
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_003717.3
Gene ID
8631
Gene #
SKAP1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SKAP1, CT (SKAP1, SCAP1, SKAP55, Src kinase-associated phosphoprotein 1, Src family-associated phosphoprotein 1, Src kinase-associated phosphoprotein of 55kD)
SKAP1, SCAP1, SKAP55, Src kinase-associated phosphoprotein 1, Src family-associated phosphoprotein 1, Src kinase-associated phosphoprotein of 55kD

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
SKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 265-295 amino acids selected from the C-terminal region of human SKAP1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Goode, E.L., et al. Nat. Genet. 42(10):874-879(2010)|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Raab, M., et al. Immunity 32(4):541-556(2010)|Lehmann, R., et al. Proteomics 9(23):5288-5295(2009)|Fang, L., et al. Cell Cycle 8(17):2819-2827(2009)
USBio References
No references available
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