Rabbit Anti-SLCO1B1, ID (SLCO1B1, LST1, OATP1B1, OATP2, OATPC, SLC21A6, Solute carrier organic anion transporter family member 1B1, Liver-specific organic anion transporter 1, OATP-C, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6)
SLCO1B1, LST1, OATP1B1, OATP2, OATPC, SLC21A6, Solute carrier organic anion transporter family member 1B1, Liver-specific organic anion transporter 1, OATP-C, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6
SLCO1B1 is a liver-specific member of the organic anion transporter family. This protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.
Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 267-293 in the central region of human SLCO1B1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human SLCO1B1.
