Technical Data

042141
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_003095.2
Gene ID
6652
Gene #
SORD
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SORD, ID (SORD, Sorbitol dehydrogenase, L-iditol 2-dehydrogenase)
SORD, Sorbitol dehydrogenase, L-iditol 2-dehydrogenase

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
SORD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 amino acids from the Central region of human SORD.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Szabo, Z., et al. Oncol. Rep. 23(5):1233-1239(2010)|Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :|El-Kabbani, O., et al. Curr. Med. Chem. 11(4):465-476(2004)|Pauly, T.A., et al. Structure 11(9):1071-1085(2003)|Darmanin, C., et al. Acta Crystallogr. D Biol. Crystallogr. 59 (PT 3), 558-560 (2003) :
USBio References
No references available
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