Technical Data

042291
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_005408.1
Gene ID
6714
Gene #
SRC
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SRC, NT (SRC, SRC1, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src)
SRC, SRC1, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
SRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human SRC.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Pradhan, S., et al. J. Biol. Chem. 285(38):29059-29068(2010)|Dergai, M., et al. Biochem. Biophys. Res. Commun. 399(2):307-312(2010)|Liu, H., et al. J. Biol. Chem. 285(29):21934-21942(2010)|Pene-Dumitrescu, T., et al. J. Biol. Chem. 285(28):21446-21457(2010)|Liu, X., et al. Acta Biochim. Biophys. Sin. (Shanghai) 42(7):496-501(2010)
USBio References
No references available
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