Technical Data

042564
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_001171525.1; NP_037383.1
Gene ID
6866
Gene #
TAC3
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TAC3, ID (TAC3, NKNB, Tachykinin-3, ZNEUROK1, Neurokinin-B, Neuromedin-K)
TAC3, NKNB, Tachykinin-3, ZNEUROK1, Neurokinin-B, Neuromedin-K

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants.

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-83 amino acids from the Central region of human TAC3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Klassert, T.E., et al. J. Neuroimmunol. 227 (1-2), 202-207 (2010) :|Hrabovszky, E., et al. Eur. J. Neurosci. 31(11):1984-1998(2010)|Gianetti, E., et al. J. Clin. Endocrinol. Metab. 95(6):2857-2867(2010)|Young, J., et al. J. Clin. Endocrinol. Metab. 95(5):2287-2295(2010)|Semple, R.K., et al. Front Horm Res 39, 133-141 (2010) :
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net