Technical Data

042853
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_849223.2
Gene ID
99929
Gene #
Tiparp
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-Tiparp, CT (Tiparp, TCDD-inducible poly [ADP-ribose] polymerase, ADP-ribosyltransferase diphtheria toxin-like 14)
Tiparp, TCDD-inducible poly [ADP-ribose] polymerase, ADP-ribosyltransferase diphtheria toxin-like 14

Tiparp is a poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:50-100
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Tiparp antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the C-terminal region of human Tiparp.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Schmahl, J., et al. Genes Dev. 22(23):3255-3267(2008)|Schmahl, J., et al. Nat. Genet. 39(1):52-60(2007)|Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)|Ma, Q. Arch. Biochem. Biophys. 404(2):309-316(2002)|Ma, Q., et al. Biochem. Biophys. Res. Commun. 289(2):499-506(2001)
USBio References
No references available
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