Technical Data

042868
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_008936.2
Gene ID
7091
Gene #
TLE4
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TLE4, NT (TLE4, KIAA1261, Transducin-like enhancer protein 4)
TLE4, KIAA1261, Transducin-like enhancer protein 4

TLE4 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TLE4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-196 amino acids from the N-terminal region of human TLE4.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :|Hancock, D.B., et al. PLoS Genet. 5 (8), E1000623 (2009) :|Stolk, L., et al. Nat. Genet. (2009) In press :|Dayyani, F., et al. Blood 111(8):4338-4347(2008)|Heimbucher, T., et al. Mol. Cell. Biol. 27(1):340-351(2007)
USBio References
No references available
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