Technical Data

042912
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_009198.4; NP_001120670.1
Gene ID
11322
Gene #
TMC6
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TMC6, NT (TMC6, EVER1, EVIN1, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4)
TMC6, EVER1, EVIN1, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TMC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-188 amino acids from the N-terminal region of human TMC6.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
McDermott, D.F., et al. Pediatr Dermatol 26(3):306-310(2009)|Lazarczyk, M., et al. J. Exp. Med. 205(1):35-42(2008)|Zuo, Y.G., et al. J. Dermatol. Sci. 44(3):153-159(2006)|Olsen, J.V., et al. Cell 127(3):635-648(2006)|Donfack, J., et al. Int. J. Pediatr. Otorhinolaryngol. 70(7):1235-1240(2006)
USBio References
No references available
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