Technical Data

043031
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Gene ID
259236
Gene #
TMIE
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TMIE, ID (TMIE, Transmembrane inner ear expressed protein)
TMIE, Transmembrane inner ear expressed protein

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TMIE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78~108 amino acids from the Central region of human TMIE.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Yang, J.J., et al. Int. J. Pediatr. Otorhinolaryngol. (2010) In press |Sirmaci, A., et al. Clin. Genet. 75(6):562-567(2009)|Santos, R.L., et al. J. Mol. Med. 84(3):226-231(2006)|Cho, K.I., et al. Comp. Med. 53(6):642-648(2003)|Naz, S., et al. Am. J. Hum. Genet. 71(3):632-636(2002)|Mitchem, K.L., et al. Hum. Mol. Genet. 11(16):1887-1898(2002)
USBio References
No references available
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