Technical Data

043073
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_443177.1
Gene ID
115650
Gene #
TNFRSF13C
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TNFRSF13C, NT (TNFRSF13C, BAFFR, BR3, Tumor necrosis factor receptor superfamily member 13C, B Cell-activating factor receptor, BAFF receptor, BLyS receptor 3, CD268)
TNFRSF13C, BAFFR, BR3, Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BLyS receptor 3, CD268

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1-30 in the N-terminal region of human TNFRSF13C., UniProt Accession #Q96RJ3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human TNFRSF13C.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Mihalcik, S.A., et al. J. Immunol. 185(2):1045-1054(2010) 2. Parameswaran, R., et al. Cancer Res. 70(11):4346-4356(2010) 3. Davila, S., et al. Genes Immun. 11(3):232-238(2010) 4. Yuan, H., et al. DNA Cell Biol. 29(3):133-139(2010) 5. Yuan, H.X., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(2):111-114(2010)
USBio References
No references available
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