Technical Data

043144
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001026855.2; NP_005417.1;
Gene ID
7159
Gene #
TP53BP2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TP53BP2, NT (TP53BP2, ASPP2, BBP, Apoptosis-stimulating of p53 protein 2, Bcl2-binding protein, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2)
TP53BP2, ASPP2, BBP, Apoptosis-stimulating of p53 protein 2, Bcl2-binding protein, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2

TP53BP2 is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TP53BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-122 amino acids from the N-terminal region of human TP53BP2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rose, J. Phd, et al. Mol. Med. (2010) In press :|Zhao, J., et al. Hepatology 51(1):142-153(2010)|Hirata, H., et al. J. Urol. 182(2):721-727(2009)|Kweekel, D.M., et al. Br. J. Cancer 101(2):357-362(2009)|Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
USBio References
No references available
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