Technical Data

043286
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001129427.1; NP_001129428.1
Gene ID
7223
Gene #
TRPC4
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TRPC4, CT (TRPC4, Short transient receptor potential channel 4, Trp-related protein 4)
TRPC4, Short transient receptor potential channel 4, Trp-related protein 4

Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TRPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 811-840 amino acids from the C-terminal region of human TRPC4.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Mace, K.E., et al. J. Cell. Physiol. 225(2):444-453(2010)|von Spiczak, S., et al. Neuromolecular Med. 12(3):292-299(2010)|Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Schaefer, M., et al. J. Biol. Chem. 277(5):3752-3759(2002)
USBio References
No references available
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