Technical Data

043287
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_056453.1
Gene ID
26133
Gene #
TRPC4AP
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TRPC4AP, NT (TRPC4AP, C20orf188, TRRP4AP, Short transient receptor potential channel 4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein)
TRPC4AP, C20orf188, TRRP4AP, Short transient receptor potential channel 4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TRPC4AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from the N-terminal region of human TRPC4AP.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Mace, K.E., et al. J. Cell. Physiol. 225(2):444-453(2010)|Choi, S.H., et al. Genes Dev. 24(12):1236-1241(2010)|Poduslo, S.E., et al. Neurosci. Lett. 450(3):344-346(2009)|Poduslo, S.E., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (1), 50-55 (2009) :|Tsang, H.T., et al. Genomics 88(3):333-346(2006)
USBio References
No references available
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