Technical Data

043343
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
DB E
Crossreactivity
Hu
Accession #
NP_000539.2
Gene ID
7249
Gene #
TSC2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TSC2, phosphorylated (S1096) (TSC2, TSC4, Tuberin, Tuberous sclerosis 2 protein)
TSC2, TSC4, Tuberin, Tuberous sclerosis 2 protein

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications
Suitable for use in Dot Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Dot blot 1:500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1096 of human TSC2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Slattery, M.L., et al. Carcinogenesis 31(9):1604-1611(2010)|Larson, Y., et al. J. Biol. Chem. 285(32):24987-24998(2010)|Mehta, M.S., et al. Breast Cancer Res. Treat. (2010) In press :|Mieulet, V., et al. Trends Mol Med 16(7):329-335(2010)|Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
USBio References
No references available
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