Technical Data

043357
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001138864.1
Gene ID
80746
Gene #
TSEN2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-TSEN2, NT (TSEN2, SEN2, tRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2)
TSEN2, SEN2, tRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2

This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TSEN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human TSEN2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Weitzer, S., et al. Nature 447(7141):222-226(2007)|Lamesch, P., et al. Genomics 89(3):307-315(2007)|Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)|Paushkin, S.V., et al. Cell 117(3):311-321(2004)|Nakayama, M., et al. Genome Res. 12(11):1773-1784(2002)
USBio References
No references available
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