043486
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_001166984.1Gene ID
114112Gene #
TXNRD3Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-TXNRD3, ID (TXNRD3, TGR, TRXR3, Thioredoxin reductase 3, Thioredoxin and glutathione reductase, Thioredoxin reductase TR2)
TXNRD3, TGR, TRXR3, Thioredoxin reductase 3, Thioredoxin and glutathione reductase, Thioredoxin reductase TR2
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TXNRD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human TXNRD3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Gerashchenko, M.V., et al. J. Biol. Chem. 285(7):4595-4602(2010)|Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)|Harris, S.E., et al. BMC Genet. 8, 43 (2007) :|Kryukov, G.V., et al. Science 300(5624):1439-1443(2003)|Sun, Q.A., et al. Proc. Natl. Acad. Sci. U.S.A. 98(7):3673-3678(2001)USBio References
No references available